Neuroendocrine Cell Biology

Our research

The purpose of our research is to understand how each islet cell type and each enteroendocrine cell type in the gut is affected in type 2 diabetes. Impaired islet function is necessary for type 2 diabetes to develop. Less is known on the role of gut hormones in type 2 diabetes pathophysiology.  

By identifying type 2 diabetes-induced alterations we foresee that we will understand both the causes of the disease and the body’s own defense mechanisms that try to counteract disease development. Identification of the latter holds promise for the development of therapeutic avenues.   

Our strategy to understand cell type specific alterations in type 2 diabetes is entirely based on findings in patient material using, for example, single cell- or bulk RNA sequencing and histological techniques. Leads from these studies are tested experimentally in cell models, primary cultures as well as in small and large animals. 

Aims

• Using single cell RNA sequencing, we aim to identify which cellular processes are affected by type 2 diabetes and in which islet and small intestinal cell type this occurs.
• To understand how the intestinal mucosa and regulation of incretin hormones are affected in patients subjected to gastric bypass surgery, an operation that often cures type 2 diabetes. 
• To understand the intracellular basis for the antidiabetic effects of the islet hormone CART. 

Impact

We aim to identify type 2 diabetes-induced, cell type-specific alterations in islet and intestinal cells that explain why the disease develops.

We also work to identify cellular processes and targets that could form the basis for future treatment or prevention of type 2 diabetes. 
 

Research output

Link to a list of research output by the group in Lund University’s research portal

Team members

Link to a list of team members in Lund University’s research portal